Declining signal dependence of Nrf2-MafS-regulated gene expression correlates with aging phenotypes.

ABSTRACT: Aging is a degenerative process characterized by declining molecular, cell and organ functions, and accompanied by the progressive accumulation of oxidatively damaged macromolecules. This increased oxidative damage may be causally related to an age-associated dysfunction of defense mechanisms, which effectively protect young individuals from oxidative insults. Consistently, older organisms are more sensitive to acute oxidative stress exposures than young ones. In studies on the Drosophila Nrf2 transcription factor CncC, we have investigated possible causes for this loss of stress resistance and its connection to the aging process. Nrf2 is a master regulator of antioxidant and stress defense gene expression with established functions in the control of longevity. Here, we show that the expre

SUBMITTER: Rahman MM 

PROVIDER: S-EPMC3714369 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature