Principal component analysis based feature extraction approach to identify circulating microRNA biomarkers.

ABSTRACT: The discovery and characterization of blood-based disease biomarkers are clinically important because blood collection is easy and involves relatively little stress for the patient. However, blood generally reflects not only targeted diseases, but also the whole body status of patients. Thus, the selection of biomarkers may be difficult. In this study, we considered miRNAs as biomarker candidates for several reasons. First, since miRNAs were discovered relatively recently, they have not yet been tested extensively. Second, since the number of miRNAs is relatively limited, selection is expected to be easy. Third, since they are known to play critical roles in a wide range of biological processes, their expression may be disease specific. We applied a newly proposed method to select combinat

SUBMITTER: Taguchi YH 

PROVIDER: S-EPMC3715582 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature