Involvement of PARP-1 Val762Ala polymorphism in the onset of cervical cancer in caucasian women.

ABSTRACT:

Background and objective

Data on the Val762Ala (rs1136410) polymorphism in the poly(adenosine diphosphate [ADP]-ribose) polymerase 1 (PARP-1) gene as a risk factor for various types of cancers in different ethnicities are inconsistent. We studied this association in a Caucasian population.

Methods

Using high-resolution melting curve analysis (HRM), we studied the distribution of the PARP-1 Val762Ala polymorphism in patients with cervical cancer (n = 446) and in controls (n = 491).

Results

Logistic regression analysis adjusting for age, pregnancy, oral contraceptive use, tobacco smoking, and menopausal status demonstrated that the PARP-1 Val762Ala polymorphism was associated with an increased risk of cervical cancer. The adjusted odds ratio (OR) for patients with the A

SUBMITTER: Roszak A 

PROVIDER: S-EPMC3715681 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature