Open access high throughput drug discovery in the public domain: a Mount Everest in the making.

ABSTRACT: High throughput screening (HTS) facilitates screening large numbers of compounds against a biochemical target of interest using validated biological or biophysical assays. In recent years, a significant number of drugs in clinical trails originated from HTS campaigns, validating HTS as a bona fide mechanism for hit finding. In the current drug discovery landscape, the pharmaceutical industry is embracing open innovation strategies with academia to maximize their research capabilities and to feed their drug discovery pipeline. The goals of academic research have therefore expanded from target identification and validation to probe discovery, chemical genomics, and compound library screening. This trend is reflected in the emergence of HTS centers in the public domain over the past decade, r

SUBMITTER: Roy A 

PROVIDER: S-EPMC3716285 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature