Syncope and orthostatic intolerance increase risk of brain lesions in migraineurs and controls.

ABSTRACT:

Objectives

We and others showed that migraineurs are at increased risk of subclinical and clinical ischemic brain lesions. Migraineurs also have a higher prevalence of frequent syncope and orthostatic intolerance, symptoms that are associated with transient reductions in cerebral blood flow. In this study, we assessed whether these autonomic symptoms may contribute to the increased risk of brain lesions in migraine.

Methods

Migraineurs (n = 291) and controls (n = 140) from the population-based, cross-sectional CAMERA (Cerebral Abnormalities in Migraine, an Epidemiologic Risk Analysis) cohort (aged 30-60 years, and free of other neurologic symptoms) underwent 1) brain MRI scan, and 2) structured telephone interview including questions on frequent syncope (≥5/lifetime) and ort

SUBMITTER: Kruit MC 

PROVIDER: S-EPMC3716345 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature