Mild cognitive impairment: incidence and vascular risk factors in a population-based cohort.

ABSTRACT:

Objective

We examined the incidence of mild cognitive impairment (MCI) and its potential vascular risk factors in a prospective population-based study.

Methods

An age-stratified random population-based cohort (baseline n = 1,982), followed for up to 4 years, was annually assessed for cognitive and everyday functioning. Incidence rates were calculated for both cognitive (neuropsychological [NP]-MCI) and functional (Clinical Dementia Rating [CDR] = 0.5) definitions of MCI. Several measures of vascular, metabolic, and inflammatory risk were assessed at baseline. Risk factor analyses used interval censoring survival models, followed by joint modeling of both MCI and attrition due to mortality and illness.

Results

Incidence rates for NP-MCI and CDR = 0.5 were 95 and 55 per

SUBMITTER: Ganguli M 

PROVIDER: S-EPMC3716350 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature