Migraine, depression, and brain volume: the AGES-Reykjavik Study.

ABSTRACT:

Objective

To examine the joint association of migraine headache and major depressive disorder on brain volume in older persons without dementia.

Methods

Participants (n = 4,296, 58% women) from the population-based Age, Gene/Environment Susceptibility-Reykjavik Study were assessed for migraine headache in 1967-1991 (age 51 years [range 33-65]) according to modified International Classification of Headache Disorders-II criteria. In 2002-2006 (age 76 years [range 66-96]), lifetime history of major depressive disorder (depression) was diagnosed according to DSM-IV criteria, and full-brain MRI was acquired, which was computer postprocessed into total brain volume (TBV) (gray matter [GM], white matter [WM], white matter hyperintensities) and CSF volume for each study subject. We

SUBMITTER: Gudmundsson LS 

PROVIDER: S-EPMC3716352 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature