Genetic risk factors for intracranial aneurysms: a meta-analysis in more than 116,000 individuals.

ABSTRACT:

Objective

There is an urgent need to identify risk factors for sporadic intracranial aneurysm (IA) development and rupture. A genetic component has long been recognized, but firm conclusions have been elusive given the generally small sample sizes and lack of replication. Genome-wide association studies have overcome some limitations, but the number of robust genetic risk factors for IA remains uncertain.

Methods

We conducted a comprehensive systematic review and meta-analysis of all genetic association studies (including genome-wide association studies) of sporadic IA, conducted according to Strengthening the Reporting of Genetic Association Studies and Human Genome Epidemiology Network guidelines. We tested the robustness of associations using random-effects and sensitivit

SUBMITTER: Alg VS 

PROVIDER: S-EPMC3716358 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature