Genome-wide association study identifies possible genetic risk factors for colorectal adenomas.

ABSTRACT:

Background

Colorectal cancer is the second leading cause of cancer-related death, and most colorectal cancer usually arises from colorectal adenomas. Removal of polyps reduces mortality from colorectal cancer. Colorectal adenomas are known to aggregate in families; however, the genetic determinants for risk of polyps are largely unknown.

Methods

In this study, we used data from the Tennessee Colorectal Polyp Study and the Tennessee-Indiana Adenoma Recurrence Study to conduct a GWAS of adenoma cases and controls. Our design consisted of discovery and replication phases for a total of 2,551 Caucasian adenoma cases and 3,285 Caucasian controls. We carried out logistic regression to test for association in both the discovery and replication phase and further examined the results

SUBMITTER: Edwards TL 

PROVIDER: S-EPMC3716448 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature