Genomic distribution of SINEs in Entamoeba histolytica strains: implication for genotyping.

ABSTRACT:

Background

The major clinical manifestations of Entamoeba histolytica infection include amebic colitis and liver abscess. However the majority of infections remain asymptomatic. Earlier reports have shown that some E. histolytica isolates are more virulent than others, suggesting that virulence may be linked to genotype. Here we have looked at the genomic distribution of the retrotransposable short interspersed nuclear elements EhSINE1 and EhSINE2. Due to their mobile nature, some EhSINE copies may occupy different genomic locations among isolates of E. histolytica possibly affecting adjacent gene expression; this variability in location can be exploited to differentiate strains.

Results

We have looked for EhSINE1- and EhSINE2-occupied loci in the genome sequence of Entamoeb

SUBMITTER: Kumari V 

PROVIDER: S-EPMC3716655 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature