Assessment of the genomic variation in a cattle population by re-sequencing of key animals at low to medium coverage.

ABSTRACT:

Background

Genome- and population-wide re-sequencing would allow for most efficient detection of causal trait variants. However, despite a strong decrease of costs for next-generation sequencing in the last few years, re-sequencing of large numbers of individuals is not yet affordable. We therefore resorted to re-sequencing of a limited number of bovine animals selected to explain a major proportion of the population's genomic variation, so called key animals, in order to provide a catalogue of functional variants and a substrate for population- and genome-wide imputation of variable sites.

Results

Forty-three animals accounting for about 69 percent of the genetic diversity of the Fleckvieh population, a cattle breed of Southern Germany and Austria, were sequenced with cover

SUBMITTER: Jansen S 

PROVIDER: S-EPMC3716689 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature