Early transcriptional responses of internalization defective Brucella abortus mutants in professional phagocytes, RAW 264.7.

ABSTRACT:

Background

Brucella abortus is an intracellular zoonotic pathogen which causes undulant fever, endocarditis, arthritis and osteomyelitis in human and abortion and infertility in cattle. This bacterium is able to invade and replicate in host macrophage instead of getting removed by this defense mechanism. Therefore, understanding the interaction between virulence of the bacteria and the host cell is important to control brucellosis. Previously, we generated internalization defective mutants and analyzed the envelope proteins. The present study was undertaken to evaluate the changes in early transcriptional responses between wild type and internalization defective mutants infected mouse macrophage, RAW 264.7.

Results

Both of the wild type and mutant infected macrophages showed

SUBMITTER: Cha SB 

PROVIDER: S-EPMC3716731 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature