Impact of DCS-facilitated cue exposure therapy on brain activation to cocaine cues in cocaine dependence.

ABSTRACT:

Background

The development of addiction is marked by a pathological associative learning process that imbues incentive salience to stimuli associated with drug use. Recent efforts to treat addiction have targeted this learning process using cue exposure therapy augmented with d-cycloserine (DCS), a glutamatergic agent hypothesized to enhance extinction learning. To better understand the impact of DCS-facilitated extinction on neural reactivity to drug cues, the present study reports fMRI findings from a randomized, double-blind, placebo-controlled trial of DCS-facilitated cue exposure for cocaine dependence.

Methods

Twenty-five participants completed two MRI sessions (before and after intervention), with a cocaine-cue reactivity fMRI task. The intervention consisted of 50mg

SUBMITTER: Prisciandaro JJ 

PROVIDER: S-EPMC3716842 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature