Evolution of the myosin heavy chain gene MYH14 and its intronic microRNA miR-499: muscle-specific miR-499 expression persists in the absence of the ancestral host gene.

ABSTRACT:

Background

A novel sarcomeric myosin heavy chain gene, MYH14, was identified following the completion of the human genome project. MYH14 contains an intronic microRNA, miR-499, which is expressed in a slow/cardiac muscle specific manner along with its host gene; it plays a key role in muscle fiber-type specification in mammals. Interestingly, teleost fish genomes contain multiple MYH14 and miR-499 paralogs. However, the evolutionary history of MYH14 and miR-499 has not been studied in detail. In the present study, we identified MYH14/miR-499 loci on various teleost fish genomes and examined their evolutionary history by sequence and expression analyses.

Results

Synteny and phylogenetic analyses depict the evolutionary history of MYH14/miR-499 loci where teleost specific dupl

SUBMITTER: Bhuiyan SS 

PROVIDER: S-EPMC3716903 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature