Anti-HIV-1 activity, protease inhibition and safety profile of extracts prepared from Rhus parviflora.

ABSTRACT:

Background

In the present study, extracts prepared from the leaves of Rhus parviflora Roxb. (Anacardiaceae) were evaluated for their anti-HIV activity, which have been traditionally used for the treatment of neurological disorders such as anxiety, insomnia and epilepsy.

Methods

Aqueous and 50% ethanolic extracts prepared from leaves of the plant were tested for their cytotoxicity and anti-HIV property using reporter gene based assays as well as human peripheral blood lymphocytes (PBLs). Further these extracts were evaluated for their ability to inhibit HIV-1 reverse transcriptase (RT) and protease activity. Safety profile of the extracts was determined on viability of Lactobacillus sp., secretion of pro-inflammatory cytokines by vaginal keratinocytes and transepithelial resi

SUBMITTER: Modi M 

PROVIDER: S-EPMC3716979 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature