Value of information: interim analysis of a randomized, controlled trial of goal-directed hemodynamic treatment for aged patients.

ABSTRACT:

Background

A randomized, controlled trial, intended to include 460 patients, is currently studying peroperative goal-directed hemodynamic treatment (GDHT) of aged hip-fracture patients. Interim efficacy analysis performed on the first 100 patients was statistically uncertain; thus, the trial is continuing in accordance with the trial protocol. This raised the present investigation's main question: Is it reasonable to continue to fund the trial to decrease uncertainty? To answer this question, a previously developed probabilistic cost-effectiveness model was used. That model depicts (1) a choice between routine fluid treatment and GDHT, given uncertainty of current evidence and (2) the monetary value of further data collection to decrease uncertainty. This monetary value, that is, t

SUBMITTER: Bartha E 

PROVIDER: S-EPMC3717025 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature