Retinoic acid regulates olfactory progenitor cell fate and differentiation.

ABSTRACT:

Background

In order to fulfill their chemosensory function, olfactory neurons are in direct contact with the external environment and are therefore exposed to environmental aggressive factors. Olfaction is maintained through life because, unlike for other sensory neuroepithelia, olfactory neurons have a unique capacity to regenerate after trauma. The mechanisms that control the ontogenesis and regenerative ability of these neurons are not fully understood. Here, we used various experimental approaches in two model systems (chick and mouse) to assess the contribution of retinoic acid signaling in the induction of the olfactory epithelium, the generation and maintenance of progenitor populations, and the ontogenesis and differentiation of olfactory neurons.

Results

We show tha

SUBMITTER: Paschaki M 

PROVIDER: S-EPMC3717070 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature