Clinicopathological significance of claudin-4 in gastric carcinoma.

ABSTRACT:

Background

Aberrant expression of claudin proteins has been reported in a variety of cancers. Previous studies have demonstrated that overexpression of claudin may promote tumorigenesis and metastasis through increased invasion and survival of tumor cells. However, the prognostic significance of claudin-4 in gastric cancer remains unclear.

Methods

Immunohistochemistry was used to analyze the expression of claudin-4 in 329 clinical gastric cancer specimens and 44 normal stomach samples, 21 intestinal metaplasia samples, and 21 adjacent precursor lesions dysplasia samples. Statistical analysis methods were used to evaluate the relationship between claudin-4 expression and various clinicopathological parameters. Univariate and multivariate analyses were performed, respectively,

SUBMITTER: Zhu JL 

PROVIDER: S-EPMC3717126 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature