Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children.

ABSTRACT:

Background

Concerns about stavudine (d4T) toxicity have led to increased use of abacavir (ABC) in first-line pediatric antiretroviral treatment (ART) regimens. Field experience with ABC in ART-naïve children is limited.

Methods

Deidentified demographic, clinical and laboratory data on HIV-infected children initiating ART between 2004 and 2011 in a large pediatric HIV treatment program in Johannesburg, South Africa, were used to compare viral suppression at 6 and 12 months by initial treatment regimen, time to suppression (<400 copies/mL) and rebound (>1000 copies/mL after initial suppression). Adjusted logistic regression was used to investigate confounders and calendar effects.

Results

Two thousand thirty-six children initiated either d4T/3TC- or ABC/3TC-based first-

SUBMITTER: Technau KG 

PROVIDER: S-EPMC3717192 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature