Oxidative damage in clinical ischemia/reperfusion injury: a reappraisal.

ABSTRACT:

Aims

Ischemia/reperfusion (I/R) injury is a common clinical problem. Although the pathophysiological mechanisms underlying I/R injury are unclear, oxidative damage is considered a key factor in the initiation of I/R injury. Findings from preclinical studies consistently show that quenching reactive oxygen and nitrogen species (RONS), thus limiting oxidative damage, alleviates I/R injury. Results from clinical intervention studies on the other hand are largely inconclusive. In this study, we systematically evaluated the release of established biomarkers of oxidative and nitrosative damage during planned I/R of the kidney and heart in a wide range of clinical conditions.

Results

Sequential arteriovenous concentration differences allowed specific measurements over the reperfuse

SUBMITTER: de Vries DK 

PROVIDER: S-EPMC3717197 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature