Mitochondrial phosphorylation in apoptosis: flipping the death switch.

ABSTRACT:

Significance

Apoptosis is a complex cellular process subject to multiple layers of regulation. One such layer of regulation includes post-translational modifications, including acetylation and phosphorylation. In particular, phosphorylation of proteins directly implicated in the apoptotic process has been extensively documented. Importantly, these phosphorylation events often have functional consequences, affecting the onset of apoptotic cell death.

Recent advances

Large-scale proteomics studies have identified multiple novel phosphorylation sites on proteins involved in the apoptotic process. The delineation of the regulation and functional consequences of these phosphorylation events will be important in understanding the regulatory complexity of apoptosis.

Critical iss

SUBMITTER: Niemi NM 

PROVIDER: S-EPMC3717198 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature