Potential of pretreatment neural activity in the visual cortex during emotional processing to predict treatment response to scopolamine in major depressive disorder.

ABSTRACT:

Context

The need for improved treatment options for patients with major depressive disorder (MDD) is critical. Faster-acting antidepressants and biomarkers that predict clinical response will facilitate treatment. Scopolamine produces rapid antidepressant effects and thus offers the opportunity to characterize potential biomarkers of treatment response within short periods.

Objective

To determine if baseline brain activity when processing emotional information can predict treatment response to scopolamine in MDD.

Design

A double-blind, placebo-controlled, crossover study together with repeated functional magnetic resonance imaging, acquired as participants performed face-identity and face-emotion working memory tasks.

Setting

National Institute of Mental Health

SUBMITTER: Furey ML 

PROVIDER: S-EPMC3717361 | biostudies-literature | 2013 Mar

REPOSITORIES: biostudies-literature