Methods used to conduct and report Bayesian mixed treatment comparisons published in the medical literature: a systematic review.

ABSTRACT:

Objectives

To identify published closed-loop Bayesian mixed treatment comparisons (MTCs) and to summarise characteristics regarding their conduct and reporting.

Design

Systematic review.

Methods

We searched multiple bibliographic databases (January 2006-31 July 2011) for full-text, English language publications of Bayesian MTCs comparing the effectiveness or safety of ≥3 interventions based on randomised controlled trials and having at least one closed loop. Methodological and reporting characteristics of MTCs were extracted in duplicate and summarised descriptively.

Results

We identified 34 Bayesian MTCs spanning 13 clinical areas. Publication of MTCs increased over the 5-year period; with 76.5% published during or after 2009. MTCs included a mean (±SD) of 35.

SUBMITTER: Sobieraj DM 

PROVIDER: S-EPMC3717466 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature