Glucose metabolism in the insula and cingulate is affected by systemic inflammation in humans.

ABSTRACT:

Unlabelled

Depression is associated with systemic inflammation, and the systemic inflammation caused by endotoxin administration elicits mild depressive symptoms such as fatigue and reduced interest. The neural correlates of depressive symptoms that result from systemic inflammation are poorly defined. The aim of this study was to use (18)F-FDG PET to identify brain regions involved in the response to endotoxin administration in humans.

Methods

Nine healthy subjects received double-blind endotoxin (0.8 ng/kg) and placebo on different days. (18)F-FDG PET was used to measure differences in the cerebral metabolic rate of glucose in the following regions of interest: insula, cingulate, and amygdala. Serum levels of tumor necrosis factor-α and interleukin-6 were used to gauge the

SUBMITTER: Hannestad J 

PROVIDER: S-EPMC3717572 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature