2-Aminopyrimidine as a novel scaffold for biofilm modulation.
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ABSTRACT:
SUBMITTER: Lindsey EA
PROVIDER: S-EPMC3717969 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
2-Aminopyrimidine as a novel scaffold for biofilm modulation.
Lindsey Erick A EA Worthington Roberta J RJ Alcaraz Cristina C Melander Christian C
Organic & biomolecular chemistry 20120202 13
An efficient synthetic route to a series of substituted 2-aminopyrimidine (2-AP) derivatives has been developed. Subsequent biofilm screening has allowed comparison between the biological activity of these new derivatives and that of the 2-aminoimidazole class of anti-biofilm compounds. Several derivatives displayed the ability to modulate bacterial biofilm formation, exhibiting greater activity against Gram-positive strains than Gram-negative strains. Additionally some 2-aminopyrmidines were ab ...[more]
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