The impact of self-identified race on epidemiologic studies of gene expression.

ABSTRACT: Although population differences in gene expression have been established, the impact on differential gene expression studies in large populations is not well understood. We describe the effect of self-reported race on a gene expression study of lung function in asthma. We generated gene expression profiles for 254 young adults (205 non-Hispanic whites and 49 African Americans) with asthma on whom concurrent total RNA derived from peripheral blood CD4(+) lymphocytes and lung function measurements were obtained. We identified four principal components that explained 62% of the variance in gene expression. The dominant principal component, which explained 29% of the total variance in gene expression, was strongly associated with self-identified race (P<10(-16)). The impact of these racial dif

SUBMITTER: Sharma S 

PROVIDER: S-EPMC3718033 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature