Isolated Hoxa9 overexpression predisposes to the development of lymphoid but not myeloid leukemia.

ABSTRACT: Hoxa9 is expressed in hematopoietic stem and progenitor cells, although this expression is usually diminished as these cells undergo differentiation. In addition, aberrant expression of Hoxa9 is strongly associated with both T cell and myeloid leukemia in mice and humans. Despite this strong association, enforced expression of Hoxa9 in murine bone marrow or thymus has only shown a modest ability to transform cells. To investigate this question, we used Vav regulatory elements to generate a transgenic mouse that targets Hoxa9 overexpression to all hematopoietic tissues. High-level expression of the Hoxa9 transgene in the hematopoietic compartment was associated with embryonic lethality, as no pups from founders that expressed high levels of the transgene were born live. However, offspring o

SUBMITTER: Beachy SH 

PROVIDER: S-EPMC3718276 | biostudies-literature | 2013 Jun

REPOSITORIES: biostudies-literature