Escitalopram and enhancement of cognitive recovery following stroke.

ABSTRACT:

Context

Adjunctive restorative therapies administered during the first few months after stroke, the period with the greatest degree of spontaneous recovery, reduce the number of stroke patients with significant disability.

Objective

To examine the effect of escitalopram on cognitive outcome. We hypothesized that patients who received escitalopram would show improved performance in neuropsychological tests assessing memory and executive functions than patients who received placebo or underwent Problem Solving Therapy.

Design

Randomized trial.

Setting

Stroke center.

Participants

One hundred twenty-nine patients were treated within 3 months following stroke. The 12-month trial included 3 arms: a double-blind placebo-controlled comparison of escitalopram (n

SUBMITTER: Jorge RE 

PROVIDER: S-EPMC3718472 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature