Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme.

ABSTRACT:

Background

A major barrier to effective treatment of glioblastoma multiforme (GBM) is the invasion of glioma cells into the brain parenchyma rendering local therapies such as surgery and radiation therapy ineffective. GBM patients with such highly invasive and infiltrative tumors have poor prognosis with a median survival time of only about a year. However, the mechanisms leading to increased cell migration, invasion and diffused behavior of glioma cells are still poorly understood.

Methods

In the current study, we applied quantitative proteomics for the identification of differentially expressed proteins in GBMs as compared to non-malignant brain tissues.

Results

Our study led to the identification of 23 proteins showing overexpression in GBM; these include membrane

SUBMITTER: DeSouza LV 

PROVIDER: S-EPMC3718631 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature