Construction and characterization of an infectious replication competent clone of porcine endogenous retrovirus from Chinese miniature pigs.

ABSTRACT:

Background

Xenotransplantation from animals has been considered to be a preferable approach to alleviate the shortage of human allografts. Pigs are the most suitable candidate because of the anatomical and physiological similarities shared with humans as well as ethical concerns. However, it may be associated with the risk of transmission of infectious porcine pathogens. Porcine endogenous retroviruses (PERVs) are of particular concern because they have been shown to infect human cells in vitro. To date, researches on the molecular characteristics and potential pathogenicity of PERV are still tenuous. In this report, an infectious replication competent clone of PERV from Wuzhishan pigs (WZSPs) in China was generated and characterized. This infectious clone will contribute to studie

SUBMITTER: Xiang S 

PROVIDER: S-EPMC3718662 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature