Vitamin D supplementation and breast cancer prevention: a systematic review and meta-analysis of randomized clinical trials.

ABSTRACT: In recent years, the scientific evidence linking vitamin D status or supplementation to breast cancer has grown notably. To investigate the role of vitamin D supplementation on breast cancer incidence, we conducted a systematic review and meta-analysis of randomized controlled trials comparing vitamin D with placebo or no treatment. We used OVID to search MEDLINE (R), EMBASE and CENTRAL until April 2012. We screened the reference lists of included studies and used the "Related Article" feature in PubMed to identify additional articles. No language restrictions were applied. Two reviewers independently extracted data on methodological quality, participants, intervention, comparison and outcomes. Risk Ratios and 95% Confident Intervals for breast cancer were pooled using a random-effects mod

SUBMITTER: Sperati F 

PROVIDER: S-EPMC3718745 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature