Quantitative assessment of 2q35-rs13387042 polymorphism and hormone receptor status with breast cancer risk.

ABSTRACT:

Background

The association between rs13387042 polymorphism on 2q35 and breast cancer (BC) has been widely evaluated since it was first identified through genome-wide association approach. However, the results have been inconclusive. To investigate this inconsistency, we performed a meta-analysis of all available studies dealing with the relationship between the 2q35-rs13387042 polymorphism and BC.

Methods

Databases including MEDLINE, PubMed, EMBASE, ISI web of science and CNKI (China National Knowledge Infrastructure) were searched to find relevant studies. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of association. The random-effects model was applied, addressing heterogeneity and publication bias.

Results

A total of 24 arti

SUBMITTER: Gu C 

PROVIDER: S-EPMC3718795 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature