Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet.

ABSTRACT:

Background

The intake of a Western diet enriched in animal fat has been shown to be a major risk factor for Type 2 diabetes and obesity. Previous rodent studies have indicated that these conditions may be triggered by the accumulation of the sphingolipid ceramide in insulin-sensitive tissues. However, data are lacking in this regard from both humans and non-human primates.

Objective

Here we have investigated the relationship between plasma ceramides and metabolic syndrome in Rhesus macaques fed a high-fat and high-fructose (HFFD) 'western' diet.

Methods

We investigated this relationship in cohorts of monkeys fed a HFFD for a period of 8 months to 5 years. Animals were classified as control, pre-diabetic or diabetic based on fasting plasma parameters and insulin sensit

SUBMITTER: Brozinick JT 

PROVIDER: S-EPMC3718866 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature