Ontology highlight
ABSTRACT:
SUBMITTER: Chen ZL
PROVIDER: S-EPMC3718965 | biostudies-literature | 2013 Jul
REPOSITORIES: biostudies-literature
Chen Zu-Lin ZL Yao Yao Y Norris Erin H EH Kruyer Anna A Jno-Charles Odella O Akhmerov Akbarshakh A Strickland Sidney S
The Journal of cell biology 20130715 2
Astrocytes express laminin and assemble basement membranes (BMs) at their endfeet, which ensheath the cerebrovasculature. The function of astrocytic laminin in cerebrovascular integrity is unknown. We show that ablation of astrocytic laminin by tissue-specific Cre-mediated recombination disrupted endfeet BMs and led to hemorrhage in deep brain regions of adult mice, resembling human hypertensive hemorrhage. The lack of astrocytic laminin led to impaired function of vascular smooth muscle cells ( ...[more]