MicroRNA-10A* and MicroRNA-21 modulate endothelial progenitor cell senescence via suppressing high-mobility group A2.

ABSTRACT:

Rationale

Endothelial progenitor cells (EPCs) contribute to the regeneration of endothelium. Aging-associated senescence results in reduced number and function of EPCs, potentially contributing to increased cardiac risk, reduced angiogenic capacity, and impaired cardiac repair effectiveness. The mechanisms underlying EPC senescence are unknown. Increasing evidence supports the role of microRNAs in regulating cellular senescence.

Objective

We aimed to determine whether microRNAs regulated EPC senescence and, if so, what the underlying mechanisms are.

Methods and results

To map the microRNA/gene expression signatures of EPC senescence, we performed microRNA profiling and microarray analysis in lineage-negative bone marrow cells from young and aged wild-type and apolipop

SUBMITTER: Zhu S 

PROVIDER: S-EPMC3719009 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature