Early-life overweight trajectory and CKD in the 1946 British birth cohort study.

ABSTRACT:

Background

Few studies have examined the impact of childhood obesity on later kidney disease, and consequently, our understanding is very limited.

Study design

Longitudinal population-based cohort.

Setting & participants

The Medical Research Council National Survey of Health and Development, a socially stratified sample of 5,362 singletons born in 1 week in March 1946 in England, Scotland, and Wales, of which 4,340 were analyzed.

Predictor

Early-life overweight latent classes (never, prepubertal only, pubertal onset, or always), derived from repeated measurements of body mass index between ages 2 and 20 years.

Outcomes & measurements

The primary outcome was chronic kidney disease (CKD), defined as creatinine- or cystatin C-based estimated glomerular filt

SUBMITTER: Silverwood RJ 

PROVIDER: S-EPMC3719096 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature