Increased motor cortical facilitation and decreased inhibition in Parkinson disease.

ABSTRACT:

Objective

To identify the changes in motor cortical facilitatory and inhibitory circuits in Parkinson disease (PD) by detailed studies of their time courses and interactions.

Methods

Short-interval intracortical facilitation (SICF) and short-interval intracortical inhibition (SICI) were measured with a paired-pulse paradigm using transcranial magnetic stimulation. Twelve patients with PD in both ON and OFF medication states and 12 age-matched healthy controls were tested. The first experiment tested the time course of SICF in PD and controls. The second experiment tested SICI at different times corresponding to SICF peaks and troughs to investigate whether SICI was affected by SICF.

Results

SICF was increased in PD OFF state and was reduced by dopaminergic medications

SUBMITTER: Ni Z 

PROVIDER: S-EPMC3719423 | biostudies-literature | 2013 May

REPOSITORIES: biostudies-literature