Borrelia burgdorferi linear plasmid 28-3 confers a selective advantage in an experimental mouse-tick infection model.

ABSTRACT: Borrelia burgdorferi, the bacterium that causes Lyme disease, has a unique segmented genome consisting of numerous linear and circular plasmids and a linear chromosome. Many of these genetic elements have been found to encode factors critical for B. burgdorferi to complete the infectious cycle. However, several plasmids remain poorly characterized, and their roles during infection with B. burgdorferi have not been elucidated. To more fully characterize the role of one of the four 28-kb linear plasmids, lp28-3, we generated strains specifically lacking lp28-3 and assayed the contribution of genes carried by lp28-3 to B. burgdorferi infection. We found that lp28-3 does not carry any genes that are strictly required for infection of a mouse or tick and that lp28-3-deficient spirochetes are co

SUBMITTER: Dulebohn DP 

PROVIDER: S-EPMC3719586 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature