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First description of KPC-2-producing Klebsiella oxytoca in Brazil.

ABSTRACT: The present work reports the detection of the first case of nosocomial Klebsiella oxytoca producing class A carbapenemase KPC-2 in Brazil. The isolate KPN106 carried a 65-kb IncW-type plasmid that harbors the blaKPC gene and Tn4401b. Moreover, we detected the presence of a class 1 integron containing a new allele, arr-8, followed by a 5'-truncated dhfrIIIc gene. In view of the recent results, we emphasize the high variability of the bacterial and genetic hosts of this resistance determinant.

SUBMITTER: Almeida AC 

PROVIDER: S-EPMC3719734 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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First description of KPC-2-producing Klebsiella oxytoca in Brazil.

Almeida Anna C S AC   Cavalcanti Felipe L S FL   Martins Willames M B WM   Vilela Marinalda A MA   Gales Ana C AC   Morais Junior Marcos A MA   Morais Márcia M C MM  

Antimicrobial agents and chemotherapy 20130610 8

The present work reports the detection of the first case of nosocomial Klebsiella oxytoca producing class A carbapenemase KPC-2 in Brazil. The isolate KPN106 carried a 65-kb IncW-type plasmid that harbors the blaKPC gene and Tn4401b. Moreover, we detected the presence of a class 1 integron containing a new allele, arr-8, followed by a 5'-truncated dhfrIIIc gene. In view of the recent results, we emphasize the high variability of the bacterial and genetic hosts of this resistance determinant. ...[more]

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