Compensation of the metabolic costs of antibiotic resistance by physiological adaptation in Escherichia coli.

ABSTRACT: Antibiotic resistance is often associated with metabolic costs. To investigate the metabolic consequences of antibiotic resistance, the genomic and transcriptomic profiles of an amoxicillin-resistant Escherichia coli strain and the wild type it was derived from were compared. A total of 125 amino acid substitutions and 7 mutations that were located <1,000 bp upstream of differentially expressed genes were found in resistant cells. However, broad induction and suppression of genes were observed when comparing the expression profiles of resistant and wild-type cells. Expression of genes involved in cell wall maintenance, DNA metabolic processes, cellular stress response, and respiration was most affected in resistant cells regardless of the absence or presence of amoxicillin. The SOS respons

SUBMITTER: Handel N 

PROVIDER: S-EPMC3719774 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature