LC-MS based serum metabolomics for identification of hepatocellular carcinoma biomarkers in Egyptian cohort.

ABSTRACT: Although hepatocellular carcinoma (HCC) has been subjected to continuous investigation and its symptoms are well-known, early stage diagnosis of this disease remains difficult and the survival rate after diagnosis is typically very low (3-5%). Early and accurate detection of metabolic changes in the sera of patients with liver cirrhosis can help improve the prognosis of HCC and lead to a better understanding of its mechanism at the molecular level, thus providing patients with in-time treatment of the disease. In this study, we compared metabolite levels in sera of 40 HCC patients and 49 cirrhosis patients from Egypt by using ultraperformance liquid chromatography coupled with quadrupole time-of-flight mass spectrometer (UPLC-QTOF MS). Following data preprocessing, the most relevant ions i

SUBMITTER: Xiao JF 

PROVIDER: S-EPMC3719870 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature