Importance of inhibition of binding of complement factor H for serum bactericidal antibody responses to meningococcal factor H-binding protein vaccines.

ABSTRACT:

Background

Factor H (fH) binding protein (fHbp) is part of vaccines developed for prevention of meningococcal serogroup B disease. More than 610 fHbp amino acid sequence variants have been identified, which can be classified into 2 subfamilies. The extent of cross-protection within a subfamily has been difficult to assess because of strain variation in fHbp expression.

Methods

Using isogenic mutant strains, we compared cross-protective serum antibody responses of mice immunized with 7 divergent fHbp variants in subfamily B, including identification numbers (ID) 1 and 55, which were chosen for vaccine development.

Results and conclusions

In the presence of the human complement downregulator fH, the ability of the anti-fHbp antibodies to deposit sufficient complement C3

SUBMITTER: Konar M 

PROVIDER: S-EPMC3719908 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature