Impaired pulmonary nitric oxide bioavailability in pulmonary tuberculosis: association with disease severity and delayed mycobacterial clearance with treatment.

ABSTRACT:

Background

Nitric oxide (NO), a key macrophage antimycobacterial mediator that ameliorates immunopathology, is measurable in exhaled breath in individuals with pulmonary tuberculosis. We investigated relationships between fractional exhale NO (FENO) and initial pulmonary tuberculosis severity, change during treatment, and relationship with conversion of sputum culture to negative at 2 months.

Methods

In Papua, we measured FENO in patients with pulmonary tuberculosis at baseline and serially over 6 months and once in healthy controls. Treatment outcomes were conversion of sputum culture results at 2 months and time to conversion of sputum microscopy results.

Results

Among 200 patients with pulmonary tuberculosis and 88 controls, FENO was lower for patients with pulmona

SUBMITTER: Ralph AP 

PROVIDER: S-EPMC3719909 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature