The extracellular polysaccharide Pel makes the attachment of P. aeruginosa to surfaces symmetric and short-ranged.

ABSTRACT: Biofilms are surface-mounted, multicellular communities of microbes. Biofilms are often associated with chronic infections that resist treatment, evade the immune system, and damage host tissue. An essential characteristic of the biofilm state is that constituent organisms are bound in a polymeric matrix. This matrix gives the system spatial structure and clusters bacteria near each other, facilitating intercellular interactions. The Pseudomonas aeruginosa strain PAO1 is widely studied as a model biofilm-forming organism. The polymeric matrix of PAO1 biofilms is dominated by two bacteria-produced extracellular polymers, Pel and Psl. We use a combination of optical and atomic force microscopy to examine the roles of these polymers in very early biofilm development. In agreement with

SUBMITTER: Cooley BJ 

PROVIDER: S-EPMC3719985 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature