Nemo-like kinase associated with proliferation and apoptosis by c-Myb degradation in breast cancer.

ABSTRACT: Nemo-like kinase (NLK), a mediator of the Wnt signaling pathway, binds directly to c-Myb, leading to its phosphorylation, ubiquitination and proteasome-dependent degradation. NLK was significantly downregulated in the breast cancer tissues compared to corresponding normal tissues. NLK expression was negatively correlated with c-Myb expression. NLK suppressed proliferation, induced apoptosis and mediated c-Myb degradation in MCF-7 cells via a mechanism that seems to involve c-myc and Bcl2. These findings might provide a novel target for therapeutic intervention in patients with breast cancer.

SUBMITTER: Huang Y 

PROVIDER: S-EPMC3720543 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature