Analysis of copy number variants by three detection algorithms and their association with body size in horses.

ABSTRACT:

Background

Copy number variants (CNVs) have been shown to play an important role in genetic diversity of mammals and in the development of many complex phenotypic traits. The aim of this study was to perform a standard comparative evaluation of CNVs in horses using three different CNV detection programs and to identify genomic regions associated with body size in horses.

Results

Analysis was performed using the Illumina Equine SNP50 genotyping beadchip for 854 horses. CNVs were detected by three different algorithms, CNVPartition, PennCNV and QuantiSNP. Comparative analysis revealed 50 CNVs that affected 153 different genes mainly involved in sensory perception, signal transduction and cellular components. Genome-wide association analysis for body size showed highly signific

SUBMITTER: Metzger J 

PROVIDER: S-EPMC3720552 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature