MicroRNA-22 regulates cardiac hypertrophy and remodeling in response to stress.

ABSTRACT:

Rationale

The adult heart is composed primarily of terminally differentiated, mature cardiomyocytes that express signature genes related to contraction. In response to mechanical or pathological stress, the heart undergoes hypertrophic growth, a process defined as an increase in cardiomyocyte cell size without an increase in cell number. However, the molecular mechanism of cardiac hypertrophy is not fully understood.

Objective

To identify and characterize microRNAs that regulate cardiac hypertrophy and remodeling.

Methods and results

Screening for muscle-expressed microRNAs that are dynamically regulated during muscle differentiation and hypertrophy identified microRNA-22 (miR-22) as a cardiac- and skeletal muscle-enriched microRNA that is upregulated during myocyte d

SUBMITTER: Huang ZP 

PROVIDER: S-EPMC3720677 | biostudies-literature | 2013 Apr

REPOSITORIES: biostudies-literature