A novel approach to detect cumulative genetic effects and genetic interactions in Crohn's disease.

ABSTRACT:

Background

Genome-wide association studies have identified at least 71 Crohn's disease (CD) genetic risk loci, but the role of gene-gene interactions is unclear. The value of genetic variants in clinical practice is not defined because of limited explained heritability.

Methods

We examined model predictability of combining the 71 CD risk alleles and genetic interactions in an ongoing inflammatory bowel disease genome-wide association study. The Wellcome Trust Case Control Consortium inflammatory bowel disease genome-wide association study was used as a replicate cohort. We used logic regression, an adaptive regression methodology, to search for high-order binary predictors (e.g., single-nucleotide polymorphism [SNP] interactions).

Results

The combined 71 CD SNPs had g

SUBMITTER: Wang MH 

PROVIDER: S-EPMC3720692 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature