The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in stroke.

ABSTRACT:

Objectives

We examined the effect of Revacept, an Fc fusion protein which is specifically linked to the extracellular domain of glycoprotein VI (GPVI), on thrombus formation after vessel wall injury and on experimental stroke in mice.

Background

Several antiplatelet drugs for the treatment of myocardial infarction or ischemic stroke with potent anti-ischemic effects have been developed, but all incur a significant risk of bleeding.

Methods

Platelet adhesion and thrombus formation after endothelial injury was monitored in the carotid artery by intra-vital fluorescence microscopy. The morphological and clinical consequences of stroke were investigated in a mouse model with a one hour-occlusion of the middle cerebral artery.

Results

Thrombus formation was signific

SUBMITTER: Goebel S 

PROVIDER: S-EPMC3720811 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature