Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption.

ABSTRACT: To identify brain transcriptional networks that may predispose an animal to consume alcohol, we used weighted gene coexpression network analysis (WGCNA). Candidate coexpression modules are those with an eigengene expression level that correlates significantly with the level of alcohol consumption across a panel of BXD recombinant inbred mouse strains, and that share a genomic region that regulates the module transcript expression levels (mQTL) with a genomic region that regulates alcohol consumption (bQTL). To address a controversy regarding utility of gene expression profiles from whole brain, vs specific brain regions, as indicators of the relationship of gene expression to phenotype, we compared candidate coexpression modules from whole brain gene expression data (gathered with Affymetr

SUBMITTER: Vanderlinden LA 

PROVIDER: S-EPMC3720886 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature